In Silico Study of Coumarins: Wedelolactone as a Potential Inhibitor of the Spike Protein of the SARS-CoV-2 Variants

Figure 6

Binding interactions of inophyllum B (a, b) and inophyllum D (c, d) in the binding sites of the spike proteins of the wild-type variant and the Alpha variant, respectively. (a, c) 3D-binding interaction diagrams. (b, d) 2D-binding interaction diagrams. The protein surface of the wild-type variant is depicted as magenta for H-bond donors and green for H-bond acceptors, while the protein surface of the Alpha variant is depicted as orange for aromatic ring faces and blue for aromatic ring edges.

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