In Silico Study of Coumarins: Wedelolactone as a Potential Inhibitor of the Spike Protein of the SARS-CoV-2 Variants

Figure 7

Binding interactions of soulattrolide (a, b) and inophyllum E (c, d) in the binding sites of the spike proteins of the Beta variant and the Gamma variant, respectively. (a, c) 3D-binding interaction diagrams. (b, d) 2D-binding interaction diagrams. The protein surface of the Beta variant is depicted as blue for exposed surfaces and green for buried surfaces, while the protein surface of the Gamma variant is depicted as blue for hydrophilic surfaces and brown for hydrophobic surfaces.

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