Antidepressant and Anxiolytic Potentials of the Chewing Stick, Salvadora persica

Table 2

Effect of Sp extracts in the EPM model.

Groups	Treatment (drugs and dosage)	No. of entries in closed arms	No. of entries in open arms	Time spent in closed arms (in secs)	Time spent in open arms (in secs)
I	0.09% n/saline (p.o)	3.5 ± 0.22	0.5 ± 0.34	267.5 ± 9.54	32.5 ± 1.26
II	DZP, 1 mg/kg (p.o)	1.33 ± 0.24	4.33 ± 0.22	121.7 ± 7.93	178.3 ± 3.16
III	Sp (AE) 500 mg/kg	1.5 ± 0.32	3.66 ± 0.2	134.6 ± 3.46	165.3 ± 3.69
IV	Sp (EAE) 500 mg/kg	1.36 ± 0.2	3.83 ± 0.12	128.3 ± 3.68	171.6 ± 2.90

Each value represents mean ± SEM (n = 6).  < 0.005, in comparison with control. n/saline, normal saline; DZP, diazepam; Sp (AE), aqueous extract of Salvadora persica; Sp (EAE), ethyl acetate extract of Salvadora persica.