Antidepressant and Anxiolytic Potentials of the Chewing Stick, Salvadora persica
Table 4
Effect of Sp extracts on the light and dark model.
Groups
Treatment (drugs and dosage)
Time spent in the light box
Time spent in the dark box
No. of crossings
I
0.09% n/saline (p.o)
129.33 ± 13.57
170.67 ± 12.13
14.65 ± 3.62
II
DZP, 1 mg/kg (p.o)
201.32 ± 11.44
98.68 ± 8.97
28.24 ± 2.68
III
Sp (AE) 500 mg/kg
198.66 ± 12.73
101.34 ± 10.14
25.38 ± 2.24
IV
Sp (EAE) 500 mg/kg
212.6 ± 13.32
87.4 ± 9.32
26.92 ± 3.12
Each value represents the mean ± SEM (n = 6). < 0.001, in comparison with control; n/saline, normal saline; DZP, diazepam; Sp (AE), aqueous extract of Salvadora persica; Sp (EAE), ethyl acetate extract of Salvadora persica.