Hyperthyroidism-Associated Insulin Resistance Is Not Mediated by Adiponectin Levels
Table 1
Characteristics of control subjects and hyperthyroid subjects before and after treatment.
Control (n = 19)
Hyperthyroid (n = 19)
Pretreatment
Posttreatment
Age (years)
36.7 ± 2.7
32.6 ± 1.8
—
Sex (F/M)
17/2
14/5
—
Postmenopause
3/17
2/14
—
Body Weight (kg)
55.4 ± 1.9
53.9 ± 1.8
55.6 ± 2.0
BMI (kg/m2)*
22.9 ± 0.8
20.6 ± 0.5
21.1 ± 0.6
Free T4 (ng/dL)*
1.35 ± 0.05
5.22 ± 0.53
1.14 ± 0.09
T3 (ng/dL)*
113.1 ± 5.3
476.0 ± 46.9
115.6 ± 8.0
TSH (μIU/mL)*
1.32 ± 0.05
0.02 ± 0.00
3.47 ± 1.65
Glucose (mmol/L)
4.93 ± 0.10
5.14 ± 0.08
4.79 ± 0.12
Adiponectin (ng/L)
6.55 ± 0.71
5.57 ± 0.97
6.62 ± 0.80
Insulin (μIU/mL)
7.80 ± 1.06
8.86 ± 1.02
5.66 ± 0.69
HOMA-IR (mM mU/L)*
1.71 ± 0.23
2.06 ± 0.26
1.21 ± 0.16
TRAb (%)*
—
44.9 ± 5.7
29.1 ± 5.0
Data are mean ± SEM. Comparisons among three groups were made by one-way analysis of variance. . Post-hoc test by Bonferroni; HOMA-IR: pretreatment versus posttreatment, ; control versus pre- or posttreatment, = ns.
