Predominant RET Germline Mutations in Exons 10, 11, and 16 in Iranian Patients with Hereditary Medullary Thyroid Carcinoma

Table 1

Characterization and distribution of RET proto-oncogene germ-line mutations in exons 10, 11, 16, and intron 16 among patients with MTC and their families.

RET; mutation	Exon	Changed bp
		Normal (Mutant)	Frequency	Families
C611W	10	TGC (TGG)	0	0
C618Y	10	TGC (TAC)	5	2
C618R	10	TGC (CGC)	1	1
C618F	10	TGC (TTC)	4	4
C618S	10	TGC (AGC)	1	1
C620R	10	TGC (CGC)	1	1
C620F	10	TGC (TTC)	1	1
C634R	11	TGC (CGC)	1	1
C634Y	11	TGC (TAC)	5	3
C634G	11	TGC (GGC)	11	9
C634W	11	TGC (TGG)	1	1
C634S	11	TGC (AGC)	9	2
S686N	11	AGC>AAC	1	1
M918T	16	ATG (ACG)	2	2
Intron 16		A>T (rs3026772)	2	2
		45044G>A	1	1
		45095C>A	4	1
		45190C>A	1	1