Table of Contents Author Guidelines Submit a Manuscript
Journal of Thyroid Research
Volume 2011 (2011), Article ID 270149, 10 pages
http://dx.doi.org/10.4061/2011/270149
Research Article

Clinical Utility of Serum Interleukin-8 and Interferon-Alpha in Thyroid Diseases

1Division of Molecular Endocrinology, The Gujarat Cancer and Research Institute, NCH Compound, Asarwa, Ahmedabad 380 016, India
2Clinical Biochemistry Laboratory, The Gujarat Cancer and Research Institute, NCH Compound, Asarwa, Ahmedabad 380 016, India
3Clinical Endocrinology Department, The Gujarat Cancer and Research Institute, NCH Compound, Asarwa, Ahmedabad 380 016, India
4Medical Oncology, The Gujarat Cancer and Research Institute, NCH Compound, Asarwa, Ahmedabad 380 016, India

Received 19 August 2010; Revised 2 December 2010; Accepted 16 December 2010

Academic Editor: Oliver Gimm

Copyright © 2011 Toral P. Kobawala et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Serum interleukin-8 (IL-8) and interferon-alpha (IFN-α) levels have been estimated from a total of 88 individuals of which 19 were disease-free healthy individuals, and 69 were patients with thyroid diseases: goitre ( ), autoimmune diseases ( ), and carcinomas ( ). Both IL-8 and IFN-α were significantly higher in all the patients as compared to healthy individuals. Serum IL-8 levels showed significant positive correlation with disease stage in thyroid cancer patients. Higher serum IL-8 levels were associated with advanced disease stage while no significant correlation was observed between serum IFN-α levels and any of the clinicopathological parameters. IL-8 and IFN-α significantly correlated with each other in anaplastic carcinoma patients. Finally concluding, monitoring the serum IL-8 and IFN-α levels can help differentiate patients with thyroid diseases from healthy individuals, and IL-8 seems to have a role in the pathogenesis of thyroid diseases and may represent a target for innovative diagnostic and therapeutic strategies.