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Journal of Thyroid Research
Volume 2011 (2011), Article ID 270149, 10 pages
http://dx.doi.org/10.4061/2011/270149
Research Article

Clinical Utility of Serum Interleukin-8 and Interferon-Alpha in Thyroid Diseases

1Division of Molecular Endocrinology, The Gujarat Cancer and Research Institute, NCH Compound, Asarwa, Ahmedabad 380 016, India
2Clinical Biochemistry Laboratory, The Gujarat Cancer and Research Institute, NCH Compound, Asarwa, Ahmedabad 380 016, India
3Clinical Endocrinology Department, The Gujarat Cancer and Research Institute, NCH Compound, Asarwa, Ahmedabad 380 016, India
4Medical Oncology, The Gujarat Cancer and Research Institute, NCH Compound, Asarwa, Ahmedabad 380 016, India

Received 19 August 2010; Revised 2 December 2010; Accepted 16 December 2010

Academic Editor: Oliver Gimm

Copyright © 2011 Toral P. Kobawala et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. http://www.endocrinologist.com/thyroid.htm.
  2. J. M. G. Blesa, E. G. Pulido, M. P. Pulla et al., “Old and new insights in the treatment of thyroid carcinoma,” Journal of Thyroid Research, vol. 2010, Article ID 279468, 16 pages, 2010. View at Publisher · View at Google Scholar
  3. Y. S. Venkatesh, N. G. Ordonez, P. N. Schultz, R. C. Hickey, H. Goepfert, and N. A. Samaan, “Anaplastic carcinoma of the thyroid. A clinicopathologic study of 121 cases,” Cancer, vol. 66, no. 2, pp. 321–330, 1990. View at Publisher · View at Google Scholar · View at Scopus
  4. M. L. Carcangiu, T. Steeper, G. Zampi, and J. Rosai, “Anaplastic thyroid carcinoma: a study of 70 cases,” American Journal of Clinical Pathology, vol. 83, no. 2, pp. 135–158, 1985. View at Google Scholar · View at Scopus
  5. E. Ron, “Epidemiology of thyroid cancer,” in Cancer Epidemiology and Prevention, D. Schottenfeld and J. R. Fraumeni Jr., Eds., pp. 1000–1021, Oxford University Press, Oxford, UK, 1996. View at Google Scholar
  6. S. Franceschi, S. Preston-Martin, L. Dal Maso et al., “A pooled analysis of case-control studies of thyroid cancer. IV. Benign thyroid diseases,” Cancer Causes and Control, vol. 10, no. 6, pp. 583–595, 1999. View at Google Scholar
  7. F. Balkwill and A. Mantovani, “Inflammation and cancer: back to Virchow?” Lancet, vol. 357, no. 9255, pp. 539–545, 2001. View at Publisher · View at Google Scholar · View at Scopus
  8. M. Philip, D. A. Rowley, and H. Schreiber, “Inflammation as a tumor promoter in cancer induction,” Seminars in Cancer Biology, vol. 14, no. 6, pp. 433–439, 2004. View at Publisher · View at Google Scholar · View at Scopus
  9. L. M. Coussens and Z. Werb, “Inflammation and cancer,” Nature, vol. 420, no. 6917, pp. 860–867, 2002. View at Publisher · View at Google Scholar · View at Scopus
  10. A. Mantovani, P. Allavena, A. Sica, and F. Balkwill, “Cancer-related inflammation,” Nature, vol. 454, no. 7203, pp. 436–444, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. F. De Vita, M. Orditura, G. Galizia et al., “Serum interleukin-10 levels in patients with advanced gastrointestinal malignancies,” Cancer, vol. 86, no. 10, pp. 1936–1943, 1999. View at Publisher · View at Google Scholar · View at Scopus
  12. M. R. Shurin, G. V. Shurin, A. Lokshin et al., “Intratumoral cytokines/chemokines/growth factors and tumor infiltrating dendritic cells: friends or enemies?” Cancer and Metastasis Reviews, vol. 25, no. 3, pp. 333–356, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. R. A. Ajjan and A. P. Weetman, “Cytokines in thyroid autoimmunity,” Autoimmunity, vol. 36, no. 6-7, pp. 351–359, 2003. View at Publisher · View at Google Scholar · View at Scopus
  14. E. Tartour and W. H. Fridman, “Cytokines and cancer,” International Reviews of Immunology, vol. 16, no. 5-6, pp. 683–704, 1998. View at Google Scholar · View at Scopus
  15. M. Baggiolini, A. Walz, and S. L. Kunkel, “Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils,” Journal of Clinical Investigation, vol. 84, no. 4, pp. 1045–1049, 1989. View at Google Scholar · View at Scopus
  16. M. Baggiolini, B. Dewald, and B. Moser, “Interleukin-8 and related chemotactic cytokines—CXC and CC chemokines,” Advances in Immunology, vol. 55, pp. 97–179, 1994. View at Google Scholar · View at Scopus
  17. K. Xie, “Interleukin-8 and human cancer biology,” Cytokine and Growth Factor Reviews, vol. 12, no. 4, pp. 375–391, 2001. View at Publisher · View at Google Scholar · View at Scopus
  18. N. Iwahashi, H. Murakami, Y. Nimura, and M. Takahashi, “Activation of RET tyrosine kinase regulates interleukin-8 production by multiple signaling pathways,” Biochemical and Biophysical Research Communications, vol. 294, no. 3, pp. 642–649, 2002. View at Publisher · View at Google Scholar · View at Scopus
  19. R. K. Singh, M. Gutman, R. Radinsky, C. D. Bucana, and I. J. Fidler, “Expression of interleukin 8 correlates with the metastatic potential of human melanoma cells in nude mice,” Cancer Research, vol. 54, no. 12, pp. 3242–3247, 1994. View at Google Scholar · View at Scopus
  20. A. R. Green, V. L. Green, M. C. White, and V. Speirs, “Expression of cytokine messenger RNA in normal and neoplastic human breast tissue: identification of interleukin-8 as a potential regulatory factor in breast tumours,” International Journal of Cancer, vol. 72, no. 6, pp. 937–941, 1997. View at Publisher · View at Google Scholar · View at Scopus
  21. Y. Kitadai, K. Haruma, K. Sumii et al., “Expression of interleukin-8 correlates with vascularity in human gastric carcinomas,” American Journal of Pathology, vol. 152, no. 1, pp. 93–100, 1998. View at Google Scholar · View at Scopus
  22. M. Miyamoto, Y. Shimizu, K. Okada, Y. Kashii, K. Higuchi, and A. Watanabe, “Effect of interleukin-8 on production of tumor-associated substances and autocrine growth of human liver and pancreatic cancer cells,” Cancer Immunology Immunotherapy, vol. 47, no. 1, pp. 47–57, 1998. View at Publisher · View at Google Scholar · View at Scopus
  23. J. Akiba, H. Yano, S. Ogasawara, K. Higaki, and M. Kojiro, “Expression and function of interleukin-8 in human hepatocellular carcinoma,” International journal of oncology, vol. 18, no. 2, pp. 257–264, 2001. View at Google Scholar · View at Scopus
  24. H.-J. Seo, K.-K. Park, S. S. Han et al., “Cytokine serum levels in soft tissue sarcoma patients: correlations with clinico-pathological features and prognosis,” International Journal of Cancer, vol. 100, no. 4, pp. 463–471, 2002. View at Publisher · View at Google Scholar
  25. S. Molica, G. Vitelli, D. Levato, L. Levato, A. Dattilo, and G. M. Gandolfo, “Clinico-biological implications of increased serum levels of interleukin-8 in B-cell chronic lymphocytic leukemia,” Haematologica, vol. 84, no. 3, pp. 208–211, 1999. View at Google Scholar · View at Scopus
  26. S. Retzlaff, T. Padró, P. Koch et al., “Interleukin 8 and Flt3 ligand as markers of advanced disease in primary gastrointestinal non-Hodgkin's lymphoma,” Oncology reports, vol. 9, no. 3, pp. 525–527, 2002. View at Google Scholar · View at Scopus
  27. S. Ugurel, G. Rappl, W. Tilgen, and U. Reinhold, “Increased serum concentration of angiogenic factors in malignant melanoma patients correlates with tumor progression and survival,” Journal of Clinical Oncology, vol. 19, no. 2, pp. 577–583, 2001. View at Google Scholar · View at Scopus
  28. E. D. Bazhanova, “Participation of interferon-alpha in regulation of apoptosis,” Journal of Evolutionary Biochemistry and Physiology, vol. 41, no. 2, pp. 127–133, 2005. View at Publisher · View at Google Scholar · View at Scopus
  29. S. Giosuè, M. Casarini, L. Alemanno et al., “Effects of aerosolized interferon-α in patients with pulmonary tuberculosis,” American Journal of Respiratory and Critical Care Medicine, vol. 158, no. 4, pp. 1156–1162, 1998. View at Google Scholar · View at Scopus
  30. F. Linkov, R. L. Ferris, Z. Yurkovetsky et al., “Multiplex analysis of cytokines as biomarkers that differentiate benign and malignant thyroid diseases,” Proteomics—Clinical Applications, vol. 2, no. 12, pp. 1575–1585, 2008. View at Publisher · View at Google Scholar · View at Scopus
  31. A. Bossowski and M. Urban, “Serum levels of cytokines in children and adolescents with Graves' disease and non-toxic nodular goiter,” Journal of Pediatric Endocrinology and Metabolism, vol. 14, no. 6, pp. 741–747, 2001. View at Google Scholar · View at Scopus
  32. A. Siddiqi, J. P. Monson, D. F. Wood, G. M. Besser, and J. M. Burrin, “Serum cytokines in thyrotoxicosis,” Journal of Clinical Endocrinology and Metabolism, vol. 84, no. 2, pp. 435–439, 1999. View at Publisher · View at Google Scholar · View at Scopus
  33. G. E. Krassas, M. Bougoulia, and G. Koliakos, “Serum interleukin-8 levels in thyroid diseases,” Thyroid, vol. 10, no. 5, pp. 445–446, 2000. View at Google Scholar · View at Scopus
  34. W. Y. Lee, J. Y. Suh, S. W. Kim et al., “Circulating IL-8 and IL-10 in euthyroid sick syndromes following bone marrow transplantation,” Journal of Korean medical science, vol. 17, no. 6, pp. 755–760, 2002. View at Google Scholar · View at Scopus
  35. A. Antonelli, M. Rotondi, P. Fallahi et al., “High levels of circulating CXC chemokine ligand 10 are associated with chronic autoimmune thyroiditis and hypothyroidism,” Journal of Clinical Endocrinology and Metabolism, vol. 89, no. 11, pp. 5496–5499, 2004. View at Publisher · View at Google Scholar · View at Scopus
  36. A. Antonelli, M. Rotondi, S. M. Ferrari et al., “Interferon-γ-inducible α-chemokine CXCL10 involvement in Graves' ophthalmopathy: modulation by peroxisome proliferator-activated receptor-γ agonists,” Journal of Clinical Endocrinology and Metabolism, vol. 91, no. 2, pp. 614–620, 2006. View at Publisher · View at Google Scholar · View at Scopus
  37. YI. Ren, R. T. P. Poon, H. T. Tsui et al., “Interleukin-8 serum levels in patients with hepatocellular carcinoma: correlations with clinicopathological features and prognosis,” Clinical Cancer Research, vol. 9, no. 16, pp. 5996–6001, 2003. View at Google Scholar · View at Scopus
  38. H.-J. Seo, K.-K. Park, S. S. Han et al., “Cytokine serum levels in soft tissue sarcoma patients: correlations with clinico-pathological features and prognosis,” International Journal of Cancer, vol. 100, no. 4, pp. 463–471, 2002. View at Publisher · View at Google Scholar
  39. S. Molica, G. Vitelli, D. Levato, L. Levato, A. Dattilo, and G. M. Gandolfo, “Clinico-biological implications of increased serum levels of interleukin-8 in B-cell chronic lymphocytic leukemia,” Haematologica, vol. 84, no. 3, pp. 208–211, 1999. View at Google Scholar · View at Scopus
  40. S. Retzlaff, T. Padró, P. Koch et al., “Interleukin 8 and Flt3 ligand as markers of advanced disease in primary gastrointestinal non-Hodgkin's lymphoma,” Oncology Reports, vol. 9, no. 3, pp. 525–527, 2002. View at Google Scholar · View at Scopus
  41. S. Ugurel, G. Rappl, W. Tilgen, and U. Reinhold, “Increased serum concentration of angiogenic factors in malignant melanoma patients correlates with tumor progression and survival,” Journal of Clinical Oncology, vol. 19, no. 2, pp. 577–583, 2001. View at Google Scholar · View at Scopus
  42. H. Uehara, P. Troncoso, D. Johnston et al., “Expression of interleukin-8 gene in radical prostatectomy specimens is associated with advanced pathologic stage,” Prostate, vol. 64, no. 1, pp. 40–49, 2005. View at Publisher · View at Google Scholar · View at Scopus
  43. K. H. Lee, S. H. Bae, J. L. Lee et al., “Relationship between urokinase-type plasminogen receptor, interleukin-8 gene expression and clinicopathological features in gastric cancer,” Oncology, vol. 66, no. 3, pp. 210–217, 2004. View at Publisher · View at Google Scholar · View at Scopus
  44. Y. C. Chung and Y. F. Chang, “Significance of inflammatory cytokines in the progression of colorectal cancer,” Hepatogastroenterology, vol. 50, no. 54, pp. 1910–1913, 2003. View at Google Scholar · View at Scopus
  45. A. Yuan, J. J. Chen, P. L. Yao, and P. C. Yang, “The role of interleukin-8 in cancer cells and microenvironment interaction,” Frontiers in Bioscience, vol. 10, pp. 853–865, 2005. View at Google Scholar · View at Scopus