Effects of Supraphysiological Doses of Levothyroxine on Sleep in Healthy Subjects: A Prospective Polysomnography Study

Table 2

Heart rate and respiration rate at baseline and during maximal dosage of levothyroxine (L-T4)¹.

Physiological parameter	Baseline		During T4 treatment		Δ^2		𝑃
	Median	Quartile range	Median	Quartile range	Median	Quartile range
Heart rate/beats per minute
S2	64.4	55.1–72.7	81.4	75.1–87.2	18.9	12.5–20.8	.0002
SWS	66.8	56.6–75.6	83.3	75.8–87.1	18.6	11.5–20.6	.0012
REM	72.0	56.4–74.3	84.0	76.1–88.0	14.9	10.5–20.4	.0002
Respiration rate/per minute
S2	15.3	14.2–17.0	17.4	16.4–19.7	2.0	1.6–2.9	.0010
SWS	15.3	14.5–17.4	17.2	16.2–20.3	1.6	1.1–3.0	.0005
REM	16.7	15.1–17.5	19.9	16.9–22.1	3.2	1.3–4.1	.0005

1For abbreviations see text.
²Δ refers to intraindividual differences.