Research Article
Effects of Supraphysiological Doses of Levothyroxine on Sleep in Healthy Subjects: A Prospective Polysomnography Study
Table 2
Heart rate and respiration rate at baseline and during maximal dosage of levothyroxine (L-T4)1.
| Physiological parameter | Baseline | During T4 treatment | | | Median | Quartile range | Median | Quartile range | Median | Quartile range |
|
Heart rate/beats per minute | | | | | | S2 | 64.4 | 55.1–72.7 | 81.4 | 75.1–87.2 | 18.9 | 12.5–20.8 | .0002 | SWS | 66.8 | 56.6–75.6 | 83.3 | 75.8–87.1 | 18.6 | 11.5–20.6 | .0012 | REM | 72.0 | 56.4–74.3 | 84.0 | 76.1–88.0 | 14.9 | 10.5–20.4 | .0002 |
|
Respiration rate/per minute | | | | | | S2 | 15.3 | 14.2–17.0 | 17.4 | 16.4–19.7 | 2.0 | 1.6–2.9 | .0010 | SWS | 15.3 | 14.5–17.4 | 17.2 | 16.2–20.3 | 1.6 | 1.1–3.0 | .0005 | REM | 16.7 | 15.1–17.5 | 19.9 | 16.9–22.1 | 3.2 | 1.3–4.1 | .0005 |
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For abbreviations see text. refers to intraindividual differences.
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