Effects of Supraphysiological Doses of Levothyroxine on Sleep in Healthy Subjects: A Prospective Polysomnography Study

Table 3

Mean core body temperature at baseline and during maximal dosage of levothyroxine (L-T4).

Temperature	Baseline		During T4 treatment		Δ^1		𝑃
	Median	Quartile range	Median	Quartile range	Median	Quartile range
Both sexes 𝑛=11
Mean	36.48	36.38–36.85	36.65	36.56–36.91	0.11	−0.18–0.33	.4014
SD	0.14	0.11–0.17	0.12	0.10–0.21	−0.02	−0.03–0.06	.9658
Females 𝑛=6
Mean	36.77	36.44–36.87	36.64	36.56–36.91	−0.07	−0.40–0.18	.8750
SD	0.14	0.09–0.14	0.15	0.10–0.21	0.02	−0.03–0.07	.4375
Males 𝑛=5
Mean	36.45	35.38–36.48	36.69	36.57–36.78	0.24	0.11–0.33	.0625
SD	0.17	0.17–0.17	0.12	0.11–1.14	−0.02	−0.05–−0.02	.4375

¹Δ refers to intraindividual differences.