Journal of Thyroid Research / 2011 / Article / Tab 5

Research Article

Maternal Thyroid Function during the Second Half of Pregnancy and Child Neurodevelopment at 6, 12, 24, and 60 Months of Age

Table 5

Associations between maternal thyroid hormone levels during pregnancy (27 weeks’ gestation) and child neurodevelopment at 5 years of age.1

Free T4Total T4TSH2
β(95% CI)β(95% CI)β(95% CI)

Performance IQ
WPPSI3−4.12(−13.73, 5.49)0.03(−1.35, 1.41)−2.26(−5.27, 0.74)

Motor Development
WRAVMA4
 Pegboard-Dominant−3.76(−15.45, 7.93)−0.97(−2.64, 0.70)0.51(−3.12, 4.15)
 Pegboard-Nondominant−4.21(−16.03, 7.61)−1.55(−3.23, 0.13)0.02(−3.65, 3.68)
McCarthy
 Draw-a-Child−5.98(−16.74, 4.77)0.10(−1.44, 1.63)0.06(−3.27, 3.39)
 Gross Motor-Leg−0.14(−1.60, 1.32)0.00(−0.22, 0.22)0.16(−0.31, 0.63)
 Gross Motor-Arm0.08(−1.51, 1.66)−0.04(−0.27, 0.19)0.04(−0.45, 0.53)

Language Development
WPPSI3 Vocabulary−0.21(−1.98, 1.57)−0.22(−0.47, 0.03)−0.37(−0.92, 0.19)
PPVT5−2.71(−14.18, 8.77)−0.89(−2.54, 0.76)−1.05(−4.66, 2.57)

Memory
McCarthy
 Words and Sentences0.10(−11.32, 11.52)−0.55(−2.17, 1.07)−1.44(−4.97, 2.09)
 Digit Span Forward4.06(−4.72, 12.83)0.77(−0.46, 2.00)−1.83(−4.51, 0.86)
 Digit Span Backward4.43(−2.55, 11.42)−0.10(−1.13, 0.94)−0.38(−2.63, 1.87)

School Readiness
Woodcock-Johnson/Muñoz
 Letter-Word−1.86(−9.33, 5.60)0.21(−0.88, 1.31)1.43(−0.94, 3.80)
 Applied Problems−3.82(−14.06, 6.42)−0.51(−2.01, 1.00)−1.48(−4.74, 1.78)

Attention
CBCL6
 ADHD7−0.10(−2.03, 1.82)0.00(−0.28, 0.27)−0.65(−1.26, −0.04)*
KCPT8
 ADHD7 Confidence Index7.52(−4.86, 19.91)0.09(−1.70, 1.87)−0.75(−4.61, 3.12)

.
1Models adjusted for maternal age, income, employment status at 6 months, country of birth, Diet Quality Index, delivery complications, PPVT score; child 5-minute APGAR, hospitalization at 1 year; number of children in home at 1 and 2 years, home density at 2 years, family structure at 1 year; season of assessment.
2Since TSH was expressed on a log2 basis, β are equal to the change in neurodevelopmental outcomes for a doubling in TSH levels.
3Weschler Preschool and Primary Scale of Intelligence.
4Wide Range Assessment of Visual Motor Ability.
5Peabody Picture Vocabulary Test.
6Child Behavior Checklist.
7Attention Deficit Hyperactivity Disorder.
8Kiddie Continuous Performance Test.

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