Journal of Thyroid Research

Review Article

Role of Estrogen in Thyroid Function and Growth Regulation

Table 4

Non-genomic estrogen effects on thyroid cells.
StudyCellsGPR30MAPKPI3kCyclin D1c-fosBcL-2Bax
Kumar et al. [42]; 2010NPA87−↑↑
KAT5−↑↑↑
WRO+↑↑↑
Zeng et al. [45]; 2007KAT5↑↓
FRO↑↓
WRO↑↓
Vivacqua et al. [46]; 2006WRO+↑↑↑
FRO+↑↑↑
ARO+↑↑↑
Manole et al. [6]; 2001HTC-TSHr↑↑
Goiter↑↑
XTC 133↑↑
NPA87 and KAT5: human papillary thyroid carcinoma cell lines; WRO and FRO: human follicular thyroid carcinoma cell lines; HTC-TSHr: human thyroid carcinoma cell line lacking endogenous TSH receptor; XTC-133: thyroid cancer cell line of Hurthle cell origin; Goiter: primary culture of human thyroid cells isolated from goiter nodules. (+): presence of expression; (−) absence of expression; (↑): increase, (↓): decrease, and (0): no effects, after E2 exposure.