Invariant NKT Cell Lines Derived from the NOD·H2^h4 Mouse Enhance Autoimmune Thyroiditis

Figure 2

Adoptive transfer of iNKT line 1F1.1 in 8–10-week-old syngeneic mice induced antibodies to thyroglobulin. Mice in panels (a) and (c) received pretreatment of iodine and received iNKT cells. Both, IgG1 and IgG2b (a and c) antibody titers in the treatment groups (posttransfer day 14) were significantly higher as compared to the control group of mice (b and d). Shown IgG1 with 𝑃<.005 and IgG2b with 𝑃=.02. Control group mice on panels (b) and (d) received iodine pretreatment but no cells. No significant increase in the antibody titer to thyroglobulin was seen in control groups.

(a)

(b)

(c)

(d)