Invariant NKT Cell Lines Derived from the NOD·H2h4 Mouse Enhance Autoimmune Thyroiditis
Figure 4
Cytokine response of two iNKT cell lines. Cells were stimulated with thyroglobulin or α-GalCer four hours prior to staining. Intracellular cytokine expressions were then detected by flow cytometry as described in methods. Both lines showed a burst of cytokines after 4 hours of stimulation. (a) Line 1F1.1 showing high levels IFN-γ, but low levels of IL-4. (b) Line 2D11 showing elevated levels of both IFN-γ and IL-4. Data represents percent of total iNKT cells expressing intracellular cytokines.
