Invariant NKT Cell Lines Derived from the NOD·H2^h4 Mouse Enhance Autoimmune Thyroiditis

Table 1

Incidence and severity of thyroiditis after transfer of iNKT cell clones to NOD·H2^h4 mice.

2-week administration of NaI	Transferred iNKT cell clone	Thyroiditis incidence	Thyroiditis severity*
			0	1	2	3	4
Yes	—	1/12	11	1	0	0	0
No	1F1.1	0/4	4	0	0	0	0
Yes	1F1.1	8/12	4	3	4	1	0
Yes	2D11	4/4	0	1	3	0	0
Yes	CD4^+ (OVA specific)	0/4	4	0	0	0	0
Yes	α-GalCer	5/9	4	1	3	0	1
Yes	Vehicle	1/7	6	1	0	0	0

*Thyroiditis severity was scored as follows: 0 for no lesions, 1 for <20% infiltration, 2 for 20–30%, 3 for >30–50%, and 4 for >50% infiltration of the thyroid.