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Journal of Thyroid Research
Volume 2011 (2011), Article ID 938257, 3 pages
http://dx.doi.org/10.4061/2011/938257
Research Article

Association between Vitiligo and Thyroid Autoimmunity

1Department of Dermatology and Venereology, Sarajevo University Clinical Center, Bolnička 25, 71 000 Sarajevo, Bosnia and Herzegovina
2Department of Clinical Pharmacology, Sarajevo University Clinical Center, Sarajevo, Bosnia and Herzegovina

Received 16 December 2010; Revised 18 February 2011; Accepted 4 March 2011

Academic Editor: Guillermo Juvenal

Copyright © 2011 Emina Kasumagic-Halilovic et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Vitiligo is a common skin disorder characterized by macular depigmentation of the skin. The etiopathogenesis of the disease is still unclear, but there is evidence that autoimmunity and endocrine disfunction may be involved. Objective. The aim of this study was to determine whether vitiligo is statistically associated with thyroid autoimmunity. Method. In a prospective case-control study, we compared the frequency of thyroid autoantibodies (thyroglobulin antibody, anti-Tg and thyroid peroxidase antibody, and anti-TPO) in 33 patients with vitiligo and in 33 healthy volunteers. Thyroid autoantibodies and thyroid hormones (thyroxine (T4), triiodothyronine (T3), and thyroid stimulating hormone (TSH) were measured in all subjects. Results. Thyroid functional abnormalities were found in 6 (18.18%) patients. Anti-Tg and anti-TPO were positive in 9 (27.27%) and 8 (24.24%) patients, respectively. In control group, only one subject (3.03%) had abnormalities in thyroid hormonal status, and two subjects had positive thyroid autoantibodies. Compared with the control group, the frequency of both anti-Tg and anti-TPO was significantly higher in those with vitiligo ( 𝑃 < . 0 5 ). Conclusion. This study shows a significant association between vitiligo and thyroid autoimmunity, and that tests to detect thyroid autoantibodies are relevant in patients with vitiligo.