Thyroid Hormone and Cardiac Disease: From Basic Concepts to Clinical Application

Figure 3

Schematic of molecular, structural, and functional changes during post-ischaemic cardiac remodeling in untreated (a) and TH-treated hearts (b). TH shortly after myocardial infarction induces favorable changes in left ventricular chamber remodeling in a time-dependent manner; TH treatment accelerates the development of cardiac hypertrophy which normalizes wall tension and reshapes left ventricular chamber towards a more ellipsoidal shape at later stages [20].