Journal of Thyroid Research / 2012 / Article / Tab 2

Clinical Study

Changes of TSH-Stimulation Blocking Antibody (TSBAb) and Thyroid Stimulating Antibody (TSAb) Over 10 Years in 34 TSBAb-Positive Patients with Hypothyroidism and in 98 TSAb-Positive Graves’ Patients with Hyperthyroidism: Reevaluation of TSBAb and TSAb in TSH-Receptor-Antibody (TRAb)-Positive Patients

Table 2

Characteristics of the 34 TSBAb-positive patients with hypothyroidism and the 98 TSAb-positive Graves’ patients with hyperthyroidism.

Number of patientsGenderAge (years)Before treatment
Men/WomenTSBAb (%)TSAb (%)TBII (%)

(I) 34 TSBAb-positive patients with hypothyroidism

Ia175/1242 ± 1794 ± 6146 ± 1095 ± 5
Ib154/1145 ± 1690 ± 9136 ± 892 ± 7
Ic21/138, 4598, 97100, 9896, 95
Ia+Ib+Ic3410/2443 ± 1892 ± 7140 ± 994 ± 7

(II) 98 TSAb-positive Graves’ patients with hyperthyroidism
IIa103/740 ± 169 ± 8839 ± 42176 ± 15
IIb133/1042 ± 1710 ± 11846 ± 19568 ± 16
IIc7318/5544 ± 1610 ± 10746 ± 39056 ± 18
IId20/240, 482, 51625, 85276, 58
IIa+IIb+IIc+IId9824/7443 ± 1710 ± 9775 ± 39657 ± 17

Values are m e a n s ± S D . I, Ia, Ib, Ic, II, IIa, IIb, IIc, and IId correspond to those in Table 1. No differences of gender and ages were noted among I, Ia, Ib, Ic, II, IIa, IIb, IIc, and IId. No differences of TSAb-, TSBAb-, and TBII-activities were noted among Ia, Ib, and Ic and among IIa, IIb, IIc, and IId.
All of the 34 TSBAb-positive patients with hypothyroidism had strongly positive TSBAb (85–103%, mean ± SD = 92 ± 7%) (Ia+Ib+Ic). Some of them had weakly positive TSAb. Their TSAb activity ranged from 92% to 240%. The TSAb activities were 180–240% in 7 (21%) of the 34 TSBAb-positive patients with hypothyroidism and were less than 180% in the other 27 patients (79%). Seven (21%) of the 34 TSBAb-positive patients with hypothyroidism had positive TSAb. TSBAb-positive patients with hypothyroidism had narrow distribution of TSBAb (82–104%, 92 ± 7%) and TSAb (92–240%, 140 ± 9%). All of the 98 Graves’ patients with hyperthyroidism had positive TSAb (250–1795%, 775 ± 396%) (IIa+IIb+IIc+IId). Some of them had TSBAb. The TSBAb activities were +40–+52% in 11 (11%) and were less than +40% in the other 87 patients (89%). Graves’ patients with hyperthyroidism had wide distributions of TSAb (250–1795%, 775 ± 396%) and TSBAb (−28–+52%, 10 ± 9%).

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