A Risk Prediction Index for Amiodarone-Induced Thyrotoxicosis in Adults with Congenital Heart Disease

Table 2

Bivariate models for AIT risk prediction (Cox proportional hazard model).

Risk factors	Parameter estimate	𝑃value; (chi square)	HR	95% CI of HR (LL, UL)
Age at start of amiodarone	−0.026	0.145	0.974	0.941	1.009
Amiodarone dose mg/kg	0.241	0.167	1.272	0.904	1.789
BMI (3 categories)	0.966	0.002	2.627	1.438	4.798
BMI (>25)	−1.903	0.002	0.149	0.045	0.499
BMI (21 to 25) (reference = BMI<21)	−1.047	0.034	0.351	0.134	0.921
Cyanotic	0.630	0.135	1.878	0.822	4.293
Goiter	1.405	0.003	4.08	1.6	10.3
Gender (reference = female)	0.019	0.964	1.02	0.45	2.3

BMI: body mass index; CI: confidence interval; HR: hazard ratio; LL: lower limit; UL: upper limit.