351864.fig.005a
(a)
351864.fig.005b
(b)
351864.fig.005c
(c)
351864.fig.005d
(d)
Figure 5: Successive development of hypothyroidism as a consequence of decreasing . Beginning with a hypothetical “sublatent” form defined by reduced and still normal levels of TSH and FT4 (panel b), further steps are subclinical hypothyroidism with increased TSH levels and FT4 still in the lowest fraction of the reference region (panel c) and overt hypothyroidism where both parameters have left their reference region (panel d). See text for additional information.