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Journal of Thyroid Research
Volume 2012, Article ID 437569, 8 pages
Review Article

New Insight into the Treatment of Advanced Differentiated Thyroid Cancer

1Department of Surgery, University of Arizona, Tucson, AZ 85724-5131, USA
2The University of Arizona Cancer Center, Tucson, AZ 85719-1454, USA

Received 3 November 2012; Accepted 12 December 2012

Academic Editor: Maria Grazia Chiofalo

Copyright © 2012 Arash Safavi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The vast majority of patients with differentiated thyroid cancer (DTC) are treated successfully with surgery and radioactive iodine ablation, yet the treatment of advanced cases is frustrating and largely ineffective. Systemic treatment with conventional cytotoxic chemotherapy is basically ineffective in most patients with advanced DTC. However, a better understanding of the genetics and biologic basis of thyroid cancers has generated opportunities for innovative therapeutic modalities, resulting in several clinical trials. We aim to delineate the latest knowledge regarding the biologic characteristics of DTC and to describe the available data related to novel targeted therapies that have demonstrated clinical effectiveness.