Clinical Study

Recombinant Human Thyrotropin-Aided Radioiodine Therapy in Patients with Metastatic Differentiated Thyroid Carcinoma

Table 1

Patients treated with rhTSH-aided radioiodine therapy.

Patient numberAge (years)GenderTumor histologyTumor stage at initial diagnosisPrimary surgical treatmentPrior THW-aided 131-I (GBq)Metastatic site(s) at time of first rhTSH-aided RITPrevious EBR and/or chemotherapy (ChT)Indication(s) for rhTSHNumber of rhTSH-aided 131-I (GBq)Clinical effect of rhTSH-aided 131-IOutcomeSurvival after the first rhTSH-aided 131-I (months)

181FFoT4N0M0Total thyroidectomy38.55BoneEBRAdvanced age, potential compressive neurological symptoms 21×PR
1×PD
Dead of other reasons22
273FHT4N0M1Total thyroidectomy27.89Bone, lungEBR, ChTProgressive paraparesis, potential additional compressive neurological and respiratory symptoms22×PRDead of other reasons81
379FHT4N0M0Total thyroidectomy39.47LungEBRAdvanced age, potential respiratory symptoms, concomitant diseases11×PDDead of metastatic disease15
463FHT4N0M1Total thyroidectomy15.65LungEBR, ChTPotential respiratory symptoms54×PD
1×SD
Dead of metastatic disease54
572FP, FVT4N0M1Total thyroidectomy68.33BoneEBR, ChTAdvanced age, potential compressive neurological symptoms33×PDAlive99
671MHT3N0M0Subtotal thyroidectomy50.32Bone, lungEBR, ChTAdvanced age, potential compressive neurological and respiratory symptoms22×PDDead of metastatic disease16
772FFo, INST4N0M1Total thyroidectomy29.60BoneEBR, ChTHistory of severe hypothyroid symptoms, hypertension, history of breast carcinoma44×PDDead of metastatic disease65
869FP, FVT4N0M0Total thyroidectomy36.04Bone, lungEBRHeart disease, potential compressive neurological and respiratory symptoms, history of severe hypothyroid symptoms22×PDDead of metastatic disease33
978FHT4N1M1Total thyroidectomy14.73Lung, right kidneyAdvanced age, potential respiratory symptoms 41×PD
2×SD
1×PD
Alive91
1062MP, FVT4N1M0Total thyroidectomy and modified RND22.64LungEBRPotential respiratory symptoms22×PDDead of metastatic disease46
1182FHT3N0M0Total thyroidectomy3.88MediastinumEBRAdvanced age, history of severe hypothyroid symptoms21×PDAlive67
1279FFoT3N0M0Total thyroidectomy21.46Bone, mediastinum, central neck compartmentEBRAdvanced age, potential compressive neurological symptoms11×PDDead of metastatic disease28
1366FFo, PoDT2N0M1Total thyroidectomy5.69Bone, brainEBR, ChTPotential neurological symptoms from metastases44×SDDead of metastatic disease24
1477FFoT3N0M0Total thyroidectomy3.58LungAdvanced age, heart disease33×SDAlive81
1564MFoT4N0M0Total thyroidectomy0Mediastinum, central neck compartmentEBRHeart disease, etilic hepatopathy, potential compressive respiratory symptoms11×PDDead of other reasons22
1658MP, PoDT4N0M0Total thyroidectomy and prophylactic mRND32.93Bone, lungEBRPotential compressive neurological and respiratory symptoms 22×PDDead of metastatic disease27
1737MPT4aN1bM1Total thyroidectomy and modified RND3.70LungEBR, ChTPotential respiratory symptoms44×SDAlive74
1883MFo T3N0M1Total thyroidectomy35.00Bone, liverAdvanced age, potential compressive neurological symptoms, concomitant diseases11×SDAlive61

F: female; Fo: follicular carcinoma; FV: follicular variant; H: Hürthle cell carcinoma; INS: insular variant; M: male; P: papillary carcinoma; PoD: poorly differentiated; RIT: radioiodine treatment; ChT: chemotherapy, EBR: external beam radiotherapy; rhTSH: recombinant human thyroid-stimulating hormone; THW: thyroid hormone withdrawal.
*UICC: International Union Against Cancer, seventh edition, 2009.
Includes remnant ablation.