Atypical Clinical Manifestations of Graves' Disease: An Analysis in Depth

Table 3

Comparison between Graves’ disease hyperthyroidism (GD) and Transient hyperthyroidism of hyperemesis Gravidarum (THHG).

	GD	THHG
Hyperthyroidism symptoms^1	Y	N
Ophthalmopathy	Y	N
Goiter	Y^2	N^3
Significant weight loss	Y	N^4
Severe vomiting	N^5	Y
TSH	Low (usually <0.01 mU/L)	Low (usually not <0.01 mU/L)
free T4	High (significant rise)	Normal (or mild rise)
Free T3	High	Normal
Persistence >1st trimester	Y	N
Treatment required	Y	N

Y: Yes; N: No, ¹tremors, marked tachycardia, muscle weakness. ²especially with a bruit. ³Thyroid gland may enlarge during normal pregnancy. ⁴may be 5% or more in severe cases of HG. ⁵Rarely severe vomiting is a hyperthyroidism feature.