Thyroid Autoantibodies in Pregnancy: Their Role, Regulation and Clinical Relevance
Tg-Ab and TPO-Ab as clinical markers.
Tg-Ab and TPO-Ab as clinical Markers
More likely to be TPO-Ab than Tg-Ab if serum positive for only one autoantibody
TPO-Ab are more prevalent than Tg-Ab in the community, and in Grave’s disease
Tg-Ab and TPO-Ab fluctuate in parallel, decreasing after antithyroid drugs, increase transiently after I131 therapy, decrease during pregnancy, increase post-partum, and are induced/enhanced by interferon-
TPO Ab Better than Tg-Ab in predicting post-partum thyroid dysfunction
Tg-Ab alone not significantly associated with disease
The comparison of thyroglobulin and TPO antibody as used as clinical markers. Adapted from McLachlan and Rapoport 2004 .