|
Study | Type of treatment | Tissue | Type of injury | Outcome |
|
Shulga et al. 2009 [18] | Treatment with T4 after injury | Mouse hippocambal slices | Mechanical injury | Increased number of neurons, reduced caspase-3 activation, and increased axonal regeneration |
Hiroi et al. 2006 [19] | Treatment with T4 after ischemia | Mouse central nervous system | Transient focal ischemia | Reduced cerebral infarct volume, and improved neurological deficit score |
Fernandez et al. 2004 [20] | Treatment with T4 after injury | Rat nervous system | Chronic demyelinating inflammatory disease | Enhancement of remyelination |
Papakostas et al. 2009 [21] | Treatment with T3 after injury | Rat sciatic nerve | Nerve transection | Increased recovery of sensory function |
Panaite and Barackat-Walter 2010 [22] | Treatment with T3 after injury | Rat sciatic nerve | Nerve transection | Increased number of regenerated axons, improved muscle reinnervation |
Fernández et al. 2007 [23] | Pretreatment with T3 | Rat Liver | Ischemia-reperfusion | Reduced injury (serum AST and ALT levels) |
Ferreyra et al. 2009 [24] | Pretreatment with T3 | Rat kidney | Ischemia-reperfusion | Reduced proteinuria |
Erkan et al. 2003 [25]
| Pretreatment with T4 | Rabbit proximal tubule cells | Anoxia reoxygenation | Better preservation of cellular structure |
Sutter et al. 1988 [26] | Treatment with T4 after ischemia | Rat kidney | Ischemia-reperfusion | Improved kidney function, preserved cellular morphology |
Verga Falzacappa et al. 2011 [27] | Contemporary T3 treatment | Mouse pancreas | Streptozocin-induced toxicity | Increased number, shape, and dimension of islets, increased insulin and glucagon levels |
Verga Falzacappa et al. 2012 [28] | Contemporary T3 treatment | Rat ovarian granulosa cells | Chemotherapy induced toxicity | Increased number of survived cells, reduced apoptosis |
Bhargava et al. 2008 [29] | Pretreatment with T3 | Rat lung | Hyperoxia injury | Increased alveolar fluid clearance |
Pantos et al. 2011 [16] | Treatment with T3 after ischemia | Rat heart | Ischemia-reperfusion | Increased recovery of function, reduced injury and apoptosis |
Pantos et al. 2009 [17] | Treatment with T3 after ischemia | Rat heart | Ischemia-reperfusion | Increased recovery of function, reduced injury |
Pantos et al. 2002 [30] | Pretreatment with T4 | Rat heart | Ischemia-reperfusion | Increased recovery of function |
Kuzman et al. 2005 [31] | Pretreatment with T3 | Neonatal rat cardiomyocytes | Serum starvation | Increased cell viability, reduced apoptosis |
Chen et al. 2008 [32] | Treatment with T3 after infarction | Rat heart | Acute myocardial infarction | Improved LV function, reduced apoptosis |
Dentice et al. 2010 [33] | Treatment with T3 after injury | Mouse skeletal muscle | Mechanical injury | Improved muscle regeneration |
Marsili et al. 2011 [34] | Induction of D2-increased T3 | Mouse skeletal muscle | Skeletal muscle injury | Improved muscle regeneration |
Fukuyama et al. 2006 [35] | Treatment with T3 after injury | Rat carotid artery | Mechanical injury | Attenuation of VSMC proliferation and neointimal formation |
Safer et al. 2004 [36] | Treatment with T3 after injury | Mouse skin | Wound | Accelerated wound healing, increased keratinocyte proliferation |
Kassem et al. 2012 [37] | Local T3 treatment | Guinea pig skin | Wound | Reduction in the wound surface area |
|