Mechanisms of L-Triiodothyronine-Induced Inhibition of Synaptosomal Na⁺-K⁺-ATPase Activity in Young Adult Rat Brain Cerebral Cortex

Figure 7

Influence of DB cAMP and T₃ on synaptosomal Na⁺-K⁺-ATPase activity, in vitro. (a) Inhibitory effect of various doses of DB cAMP on synaptosomal Na⁺-K⁺-ATPase activity, in vitro. The data are represented as mean ± SEM of four separate experiments, taking six animals in each group. The vertical bars denote SEM. (b) Interaction of the effects of of DB cAMP and T₃ on synaptosomal Na⁺-K⁺-ATPase activity, in vitro. Filled squares indicate effects of graded doses of T₃ (0.001 nM–10 nM) alone on Na⁺-K⁺-ATPase activity while filled triangles indicate effects of the 0.2 mM dose of DB cAMP with graded doses of T₃ (0.1 pM–1 μM).

(a)

(b)