Table 1: In vitro antiproliferative activity of lenvatinib against human thyroid cancer cells.

Tissue typeCell lineLenvatinib
(μM)T/N2

NormalNthy-ori 3-115

DTC3K1221.47
RO82-W-13.80.25
FTC-133241.6
FTC-236171.13
FTC-238181.2

MTC4TT0.0780.01

ATC58305C261.73
8505C261.73
TCO-1281.87
KHM-5M281.87
HTC/C3282.53

The half maximal inhibitory concentration.
2T/N: ratio of IC50 values of thyroid cancer cell lines to that of Nthy-ori 3-1 cells.
3DTC: differentiated thyroid cancer.
4MTC: medullary thyroid cancer.
5ATC: anaplastic thyroid cancer.