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Journal of Thyroid Research
Volume 2014, Article ID 913672, 6 pages
http://dx.doi.org/10.1155/2014/913672
Research Article

Elevated Serum Thyroglobulin and Low Iodine Intake Are Associated with Nontoxic Nodular Goiter among Adults Living near the Eastern Mediterranean Coast

1Department of Internal Medicine “C”, Barzilai Medical Center Ashkelon, Hahistadrout Street 2, 7830604 Ashkelon, Israel
2Nutrition and Brain Health Laboratory, School of Nutritional Sciences, Institute of Biochemistry, Food Science and Nutrition, Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, P.O. Box 12, 76100 Rehovot, Israel
3Endocrinology Clinic, Barzilai Medical Center Ashkelon, Hahistadrout Street 2, 7830604 Ashkelon, Israel
4Laboratory of Clinical Biochemistry, Barzilai Medical Center Ashkelon, Hahistadrout Street 2, 7830604 Ashkelon, Israel

Received 30 July 2014; Revised 25 November 2014; Accepted 26 November 2014; Published 14 December 2014

Academic Editor: Noriyuki Koibuchi

Copyright © 2014 Yaniv S. Ovadia et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Information about iodine intake is crucial for preventing thyroid diseases. Inadequate iodine intake can lead to thyroid diseases, including nontoxic nodular goiter (NNG). Objective. To estimate iodine intake and explore its correlation with thyroid diseases among Israeli adults living near the Mediterranean coast, where iodine-depleted desalinated water has become a major source of drinking water. Methods. Cross-sectional study of patients attending Barzilai Medical Center Ashkelon. Participants, who were classified as either NNG (), hypothyroidism (), or control (), provided serum thyroglobulin (Tg) and completed a semiquantitative iodine food frequency questionnaire. Results. Elevated serum Tg values (Tg > 60 ng/mL) were significantly more prevalent in the NNG group than in the other groups (29% versus 7% and 0% for hypothyroidism and controls, resp., ). Mean estimated iodine intake was significantly lower in the NNG group (μg/d) than in controls (μg/d) () with intermediate intake in the hypothyroid group (μg/d). Conclusions. Elevated serum Tg values and low dietary iodine intake are associated with NNG among adult patients in Ashkelon District, Israel. Larger studies are needed in order to expand on these important initial findings.