Research Article

Patient Benefit-Risk Tradeoffs for Radioactive Iodine-Refractory Differentiated Thyroid Cancer Treatments

Table 1

Attributes and levels included in the final survey instrument.

Attribute Attribute definitionLevels

Time until cancer grows (progression-free survival)One of the most important goals of cancer medicines is to keep the tumor from getting worse. Later in the survey, we will ask you to think about how long different medicines can keep the tumor from growing or getting worse.24 months
16 months
10 months
6 months

Risk of severe hand-foot skin reaction because of the medicineSome medicines to treat thyroid cancer may cause severe hand-foot skin reactions. Severe hand-foot skin reactions cause redness, pain, swelling, or blisters on the palms of your hands or soles of your feet. This type of skin reaction makes it difficult to walk or use your hands.
If you get this side effect, your doctor may change your dose or stop treatment for a period of time.
None
5 out of 100 (5%)
20 out of 100 (20%)

Risk of severe kidney problems (proteinuria) because of the medicineSome medicines to treat thyroid cancer may cause problems with your kidneys. The kidneys are organs that filter your blood and remove waste from it. This waste is released as urine.
When people have kidney problems, proteins can leak from the blood into the urine. This is known as proteinuria. Other symptoms of kidney problems include swelling of your arms and legs, poor appetite, and weight gain.
If you have severe kidney problems, your doctor may change your dose or stop treatment for a period of time to reduce the risk that you will have permanent kidney damage.
None
3 out of 100 (3%)
10 out of 100 (10%)

Risk of severe high blood pressure (hypertension) because of the medicineSome medicines to treat thyroid cancer may cause severe high blood pressure. When people have severe high blood pressure, they may experience severe headaches, tiredness that cannot be relieved by sleeping, vision problems, chest pain, and difficulty in breathing.
If you have severe high blood pressure, your doctor may change your dose or stop treatment for a period of time to reduce the risk that you have a heart attack or a stroke.
None
10 out of 100 (10%)
50 out of 100 (50%)