Research Article
Hypothyroidism in Pancreatic Cancer: Role of Exogenous Thyroid Hormone in Tumor Invasion—Preliminary Observations
Table 3
Clinicopathologic parameters of hypothyroid and euthyroid patients with invasive PDA.
| | Hypothyroid | Euthyroid | OR [95% CI] | value |
| Median survival (months) | 17.7 | 16.6 | | 0.742 | Venous-lymphatic invasion, (%) | | | 0.91 [0.52–1.58] | 0.733 | Yes | 28 (48) | 185 (51) | | | No | 30 (52) | 180 (49) | | | Perineural invasion, (%) | | | 3.38 [1.19–9.58] | 0.012 | Yes | 62 (94) | 335 (82) | | | No | 4 () | 73 () | | | T stage, (%) | | | 2.10 [1.00–4.37] | 0.045 | Low stage (T0–T2) | 9 | 98 | | | High stage (T3-T4) | 61 | 317 | | | Nodal status, (%) | | | 2.05 [1.12–3.75] | 0.018 | N0 | 15 (22) | 157 (36) | | | N1 | 54 (78) | 276 (64) | | | Prognostic stage, (%) | | | 1.89 [1.03–3.48] | 0.037 | Low stage (0–2A) | 15 (22) | 142 (34) | | | High stage (2B-3) | 54 (78) | 270 (66) | | | Differentiation, (%) | | | | 0.612 | Well | 10 (14) | 46 (12) | | | Moderate | 44 (64) | 242 (61) | | | Poor | 15 (22) | 105 (27) | | |
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Hypothyroid patients were found to have higher rates of perineural invasion, nodal spread, and advanced prognostic stage. .
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