Hypothyroidism in Pancreatic Cancer: Role of Exogenous Thyroid Hormone in Tumor Invasion—Preliminary Observations

Table 3

Clinicopathologic parameters of hypothyroid and euthyroid patients with invasive PDA.

	Hypothyroid	Euthyroid	OR [95% CI]	value
Median survival (months)	17.7	16.6		0.742
Venous-lymphatic invasion, (%)			0.91 [0.52–1.58]	0.733
Yes	28 (48)	185 (51)
No	30 (52)	180 (49)
Perineural invasion, (%)			3.38 [1.19–9.58]	0.012
Yes	62 (94)	335 (82)
No	4 ()	73 ()
T stage, (%)			2.10 [1.00–4.37]	0.045
Low stage (T0–T2)	9	98
High stage (T3-T4)	61	317
Nodal status, (%)			2.05 [1.12–3.75]	0.018
N0	15 (22)	157 (36)
N1	54 (78)	276 (64)
Prognostic stage, (%)			1.89 [1.03–3.48]	0.037
Low stage (0–2A)	15 (22)	142 (34)
High stage (2B-3)	54 (78)	270 (66)
Differentiation, (%)				0.612
Well	10 (14)	46 (12)
Moderate	44 (64)	242 (61)
Poor	15 (22)	105 (27)

Hypothyroid patients were found to have higher rates of perineural invasion, nodal spread, and advanced prognostic stage. ⁢.