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Journal of Thyroid Research
Volume 2017 (2017), Article ID 2793205, 6 pages
https://doi.org/10.1155/2017/2793205
Research Article

Does the Polymorphism in the Length of the Polyalanine Tract of FOXE1 Gene Influence the Risk of Thyroid Dysgenesis Occurrence?

1Laboratório de Erros Inatos do Metabolismo, Instituto de Ciências Fisiológicas, Universidade Federal do Pará, Belém, PA, Brazil
2Departamento de Morfologia e Ciências Fisiológicas, Universidade do Estado do Pará, Belém, PA, Brazil
3Laboratório de Cultura de Tecidos e Citogenética, SAMAM, Instituto Evandro Chagas, Ananindeua, PA, Brazil
4Instituto de Ciências Exatas e Naturais, Universidade Federal do Pará, Belém, PA, Brazil

Correspondence should be addressed to Clebson Pantoja Pimentel

Received 7 September 2017; Accepted 6 November 2017; Published 28 November 2017

Academic Editor: Marian Ludgate

Copyright © 2017 Clebson Pantoja Pimentel et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Recent data have suggested that polymorphisms in the length of the polyalanine tract (polyA) of FOXE1 gene may act as a susceptibility factor for thyroid dysgenesis. The main purpose of this study was to investigate the influence of polyA of FOXE1 gene on the risk of thyroid dysgenesis. Method. A case-control study was conducted in a sample of 90 Brazilian patients with thyroid dysgenesis and 131 controls without family history of thyroid disease. Genomic DNA was isolated from peripheral blood samples and the genotype of each individual was determined by automated sequencing. Results. More than 90% of genotypes found in the group of patients with thyroid dysgenesis and in controls subjects were represented by sizes 14 and 16 polymorphisms in the following combinations: 14/14, 14/16, and 16/16. Genotypes 14/16 and 16/16 were more frequent in the control group, while genotype 14/14 was more frequent in the group of patients with thyroid dysgenesis. There was no difference between agenesis group and control group. Genotype 14/14 when compared to genotypes 14/16 and 16/16A showed an association with thyroid dysgenesis. Conclusion. PolyA of FOXE1 gene alters the risk of thyroid dysgenesis, which may explain in part the etiology of this disease.