Distribution and Prognostic Significance of Estrogen Receptor α (ERα), Estrogen Receptor β (ERβ), and Human Epidermal Growth Factor Receptor 2 (HER-2) in Thyroid Carcinoma

Table 4

Summary of the significance of ERα, ERβ, and HER-2 expression.

Sl no.	Attribute	ERα expression	ERβ expression	HER-2 expression
1.	Gender	PTC (male) 0.043	PDTC (female) 0.014	—
2.	Tumor size	—	—	FTC (large) 0.014
3.	Presence of PDA^a	—	Whole cohort 0.026	—
4.	Multicentricity	PDTC (multicentric) 0.029; 0.037	—	—
5.	Lymph node metastases	—	Whole cohort 0.014; FTC (less) 0.023	—
6.	Distant metastases	Whole cohort (more) 0.04; 0.038	—	—

^aPDA, poorly differentiated areas. Significant values on univariate analysis. Significant values on multivariate analysis. —, nonsignificant correlation. -Attribute within bracket- significantly more.