Predictors of Improvement in Quality of Life When Treating Hypothyroidism
Table 2
Predictors of improvement in QoL (ThyPRO-39) from visit 1 to visit 3.
Predictor
Unstandardized coefficient with CI
value
REE
Change in REE/FFM from visits 1 to 3 (kcal/day per kg)
0.09 (−1.93 to 2.11)
0.93
Thyroid function
TSH at visit 1 (mU/l)
0.052 (−0.04 to 0.20)
0.37
Change in TSH from visits 1 to 3
0.053 (−0.04 to 0.20)
0.33
Increase in total T3 from visits 1 to 3 (mmol/l)
10.39 (−3.67 to 24.46)
0.14
T3 at visit 3 (mmol/l)
10.37 (−15.90 to 36.70)
0.43
Dosage
Dosage L-T4 at visit 3 (μg/week)
0.034 (0.01 to 0.06)
0.02
Dosage L-T4/FFM at visit 3 (μg/kg FFM per week)
1.05 (−0.81 to 2.91)
0.26
Age
Age (yr)
−0.38 (−0.90 to 0.13)
0.14
Body composition
BMI at visit 1(kg/m2)
1.54 (0.59 to 2.49)
0.002
FFM/FM-ratio at visit 1
−6.45 (−12.20 to −0.69)
0.03
Weight loss between visits 1 and 3 (kg)
0.33 (−1.21 to 1.27)
0.96
Cognitive function tests at visit 1
Sequential reaction time 1 (ms)
−0.03 (−0.10 to 0.04)
0.38
Sequential reaction time 2 (ms)
0.00 (−0.06 to 0.06)
0.95
SDMT score at visit 1
0.39 (−0.37 to 1.15)
0.3
Calculated with bootstrap, CI: confidence interval. The unstandardized coefficient is the estimated change in ThyPRO-39 composite score from visits 1 to 3 when changing one unit of the predicting variable. REE, resting energy expenditure; FFM, fat-free mass; FM, fat mass; kcal, 1000 calories; TSH, thyrotropin; T3, triiodothyronine; L-T4, levothyroxine; BMI, body mass index; SDMT, symbol digit modalities test.
