Association of Polygenetic Risk Scores Related to Immunity and Inflammation with Hyperthyroidism Risk and Interactions between the Polygenetic Scores and Dietary Factors in a Large Cohort

Table 2

Socioeconomic and metabolic characteristics of the participants according to hyperthyroidism.

	No hyperthyroidism (n = 38,799)	Hyperthyroidism (n = 530)	Adjusted ORs (95% CI)^15
Age^1 (years)	53.7 ± 0.04	54.6 ± 0.25	1.243 (0.967–1.599)
Age during diagnosis^2 (years)	—	47.7 ± 0.89
Gender (men: N, (%))	13,653 (35.2)	70 (13.2)	3.011(2.253–4.023)
Metabolic syndrome (N, (%))	5,471 (14.1)	72 (13.6)	0.919 (0.733–1.152)
BMI^5 (kg/m^2)^5	23.9 ± 0.01	23.4 ± 0.10	0.776 (0.658–0.911)
Waist circumference^s6	80.5 ± 0.04	80.0 ± 0.27	0.980 (0.813–1.171)
Plasma total cholesterol^7 (mg/dL)	198 ± 0.19	193 ± 1.27	0.866 (0.728–1.015)
Plasma HDL^8 (mg/dL)	54.5 ± 0.07	54.0 ± 0.45	1.004 (0.856–1.178)
Plasma triglyceride^9 (mg/dL)	126 ± 0.43	123 ± 2.84	0.918 (0.775–1.085)
Hypertension^10 (N, (%))	9,506 (24.5)	125 (23.6)	1.029 (0.860–1.239)
Type 2 diabetes^11 (N, (%))	9,968 (25.7)	202 (24.0)	1.107 (0.931–1.324)
Thyroid cancer (N, (%))	321 (0.85)	41 (7.8)	2.915 (1.905–4.467)
WBC counts^12(10^9/L)	5.71 ± 0.01	5.67 ± 0.05	0.898 (0.771–1.036)
Plasma hs-CRP^13 (ng/mL)	0.14 ± 0.002	0.17 ± 0.02	0.879 (0.563–1.37)
Education^14 (number, (%))
<High school	6,945 (17.9)	110 (20.5)	1
High school, college	8,574(22.1)	110 (20.5)	0.863 (0.681–1.094)
College and more	23,279 (60.0)	310 (58.5)	0.863 (0.681 1.094)

The values represent adjusted means ± standard errors or number (percentage) of the subjects. The cutoff points of the reference were as follows: <55 years for age; 50 years for hyperthyroidism diagnosed age; <15 years old for initial menstruation age; <50 years old for menopause age; < 25 kg/m² body mass index (BMI); < 90 cm for men and 85 cm for women waist circumferences; <230 mg/dL plasma total cholesterol concentrations; >40 mg/dL for men and 50 mg/dL for women plasma HDL cholesterol; <150 mg/dL plasma triglyceride concentrations; <140 mmHg SBP, 90 mmHg DBP plus hypertension medication; <126 ml/dL fasting serum glucose plus diabetic drug intake; <4 × 109/L white blood cell (WBC) counts; <0.5 mg/dL serum high-sensitivity C-reactive protein (hs-CRP) concentrations; high school graduation; adjusted odds ratio (ORs) and 95% confidence intervals (CI) after adjusting for covariates, including age, gender, residence areas, initial menstruation age, menopause, pregnancy experience, income, education, energy intake, seaweed intake, smoking status, physical activity, WBC counts, alcohol intake, autoimmune diseases including asthma, rheumatoid arthritis, and allergy, and survey year.