Association of Polygenetic Risk Scores Related to Immunity and Inflammation with Hyperthyroidism Risk and Interactions between the Polygenetic Scores and Dietary Factors in a Large Cohort

Table 3

Characteristics of the ten genetic variants of genes in hyperthyroidism used for the generalized multifactor dimensionality reduction analysis.

Chr^1	SNP^2	Position	Mi^3	Ma^4	OR^5	value for ORs^6	MAF^7	value for HWE^8	Gene	Functional consequence
2	rs1881145	12634278	T	A	0.90 (0.85–0.96)	7.48.E-04	0.3495	0.8488	TRIB2	Intron
2	rs231775	204732714	A	G	0.88 (0.82–0.94)	5.54.E-05	0.2938	0.7959	CTLA4	Intron
3	rs6780858	188132110	G	A	0.90 (0.85–0.96)	6.01.E-04	0.365	0.5449	LPP	Intron
6	rs1304322089	30990958	T	C	1.18 (1.10–1.26)	5.08.E-06	0.1805	0.4865	MUC22	Intron
6	rs1800610	31543827	A	G	1.21 (1.13–1.30)	9.51.E-08	0.1921	0.6802	TNF	Intron
6	rs767861647	29976789	C	T	1.13 (1.06–1.20)	1.02.E-04	0.3008	0.486	HLA-J	Intron
6	rs3117138	32306970	C	A	1.28 (1.18–1.39)	4.69.E-09	0.1163	0.4574	TSBP1	Intron
6	rs79142022	32806673	C	T	1.56 (1.29–1.88)	4.06.E-06	0.0162	0.06767	TAP2	Upstream
6	rs78117616	33603142	C	G	1.60 (1.29–2.0)	2.69.E-05	0.0121	0.601	ITPR3	Intron
8	rs7002063	31803534	A	G	1.15 (1.08–1.22)	1.41E-05	0.270	0.516	NRG1	Upstream

¹ Chromosome; ² single nucleotide polymorphism; ³ minor alleles; ⁴ major alleles; ⁵ odds ratio (OR) and 95% confidence intervals; ⁶ value for OR after adjusting for age, gender, residence area, survey year, body mass index, daily energy intake, education, and income; ⁷ minor allele frequency; and ⁸ Hardy–Weinberg equilibrium. TRIB2, tribbles pseudokinase 2; CTLA4, cytotoxic T-lymphocyte-associated antigen 4; LPP, lipoma-preferred partner; MUC22, mucin 22; TNF, tumor necrosis factor; HLA-J, human leukocyte antigen, class J; TSBP1, testis-expressed basic protein 1; TAP2, transporter 2, ATP binding cassette subfamily B member; ITPR3, inositol 1,4,5-trisphosphate receptor type 3; and NRG1, neuregulin 1.