Association of Polygenetic Risk Scores Related to Immunity and Inflammation with Hyperthyroidism Risk and Interactions between the Polygenetic Scores and Dietary Factors in a Large Cohort

Table 4

Generalized multifactor dimensionality reduction (GMDR) of genetic variant-genetic variant interaction of genes related to inflammation and immunity for hyperthyroidism risk.

GMDR	Adjusted for sex and age				Adjusted for sex, age, seaweed, and BMI
Model	TRBA^1	TEBA^2	value^3	CVC^5	TRBA	TEBA	value^4	CVC
TNF_rs1800610	0.5243	0.5206	10 (0.0010)	9/10	0.5249	0.5211	10 (0.0010)	9/10
MUC22_rs1304322089 plus model 1	0.5314	0.5264	10 (0.0010)	6/10	0.5317	0.5213	10 (0.0010)	4/10
MIR3681_rs1881145 plus model 2	0.5388	0.5224	9 (0.0107)	7/10	0.5391	0.5185	9 (0.0107)	4/10
MIR3681_rs1881145 CTLA4_rs231775 LPP_rs6780858 HLA-J_rs767861647	0.5465	0.5137	9 (0.0107)	3/10	0.5473	0.5186	9 (0.0107)	4/10
TNF_rs1800610 plus model 4	0.5622	0.5181	9 (0.0107)	8/10	0.5624	0.5205	9 (0.0107)	8/10
CTLA4_rs231775 LPP_rs6780858 HLA-J_rs767861647 plus model 3	0.5880	0.5205	9 (0.0107)	10/10	0.5888	0.5221	10 (0.0010)	10/10
TSBP1_rs3117138 plus model 6	0.6164	0.5168	9 (0.0107)	10/10	0.6172	0.5193	9 (0.0107)	10/10
NRG1_rs7002063 plus model 7	0.6454	0.5211	8 (0.0547)	10/10	0.6462	0.5221	10 (0.0010)	10/10
TSBP1_rs3117138 ITPR3_rs78117616 plus model 7	0.6515	0.5158	8 (0.0547)	7/10	0.6522	0.5193	9 (0.0107)	6/10
TAP2_rs79142022 plus model 9	0.6550	0.5176	9 (0.0107)	10/10	0.6558	0.5228	9 (0.0107)	10/10

¹ Trained balanced accuracy; ² test balance accuracy; ^3,4 value for the significance of GMDR model by sign test. ³ without and ⁴ with adjusting for covariates; ⁵ crossvalidation consistency; and BMI, body mass index.