Modulating Thyroid Hormone Levels in Adult Mice: Impact on Behavior and Compensatory Brain Changes

Figure 5

Elevated plus maze (EPM) test of treated mice. EPM was performed at four months of treatment. (a) Animals with apparent low anxiety and increased exploration will spend more time in the open arms while those with increased anxiety spend more time in the closed arms. (b) Representative raw data are shown for each treatment group. (c) Although thyroxine treatment had no effect on immobility during the elevated plus maze, PTU/Met-treated mice spent more time immobile. (d) PTU/Met-treated mice moved at a significantly lower velocity than either control or thyroxine-treated mice. (e) Thyroxine-treated mice spent significantly more time in the open arm, whereas PTU/Met-treated mice spent significantly less time than control mice. (f) Thyroxine-treated mice spent less time in the closed arms. There was no difference between PTU/Met and control-treated mice. compared with control. Control = 7 M/6 F, thyroxine = 7 M/6 F, and PTU = 5 M/8 F.

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