Persistence of Hepatitis C RNA in Liver Allografts Is Associated with Histologic Progression Independent of Serologic Viral Clearance

Table 4

HCV viral loads, ALT, and modified Ishak score grade and stage for groups 1 and 2, at 4 months post LT and at the ISH biopsy.

Variables	Group 1 ISH positive 𝑁=10	Group 2 ISH negative 𝑁=15	𝑃
4 month HCV titer x1,000,000 IU/ml	1.2 ± 15	2.4 ± 4.4	.32
4 month ALT IU	126 ± 92	168 ± 205	.68
4 month grade	3.6 ± 2.5	3.6 ± 2.7	.9
4 month stage	1 ± 1.2	0.5 ± 0.5	.39
4 month to ISH biopsy interval, months	19 ± 10	19 ± 12	.93
ISH biopsy ALT IU	69 ± 45	32 ± 27	.016
ISH biopsy grade	3 ± 1.7	1.6 ± 1.3	.039
ISH biopsy stage	1.4 ± 1.4	0.5 ± 0.6	.084