Journal of Transplantation / 2009 / Article / Tab 4

Review Article

A Comprehensive Review of Immunosuppression Used for Liver Transplantation

Table 4

Investigational immunosuppressive agents in liver transplantation.

Immunosuppressive agentTarget pathway

FK778Interferes with pyrimidine metabolism and DNA synthesis
JAK inhibitorsInterfere with Signal 3 transduction
FTY720Inhibits T cell migration to venule endothelial cells in secondary lymphoid tissue
LEA29YInterferes with Signal 2 via inhibition of B7/CD28 interaction

Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.