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Journal of Transplantation
Volume 2010 (2010), Article ID 273578, 4 pages
Case Report

Percutaneous Liver Biopsy after Living Donor Liver Transplantation Resulting in Fulminant Hepatic Failure: The First Reported Case of Hepatic Compartment Syndrome

1Hepatology and Liver Transplantation, Cedars-Sinai Medical Center, 8635 W. 3rd Street #1060-W, Los Angeles, CA 90048, USA
223961 Calle De La Magdalena, Laguna Hills, CA 92653, USA
32601 East Main St., Suite 102, Ventura, CA 93003, USA

Received 12 December 2009; Accepted 4 February 2010

Academic Editor: Paul C. Kuo

Copyright © 2010 Nicholas N. Nissen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A 28-year-old female who underwent live donor liver transplantation 3 years prior presented after percutaneous liver biopsy with abdominal and shoulder pain, nausea, vomiting, and elevated liver enzymes. Computed tomography (CT) showed an intrahepatic and subcapsular hematoma. There was a progressive increase in liver enzymes, bilirubin, and INR and a decline in hemoglobin. Subsequent CT imaging revealed flattening of the portal vein consistent with compression by the enlarging hematoma. Liver failure ensued and the patient required urgent retransplantation. The explant demonstrated ischemic necrosis of greater than 90% of the liver parenchyma. We report this case of “Hepatic Compartment Syndrome” leading to fulminant hepatic failure.