Prognostic Factors for Tumor Recurrence after a 12-Year, Single-Center Experience of Liver Transplantations in Patients with Hepatocellular Carcinoma

Table 1

Demographic, clinical, and pathological parameters of 283 patients with HCC receiving OLT at the Bologna Center between 1997 and 2009.

Variables
Gender
Male	241 (85%)
Female	42 (15%)
Median age (years)	57 (33–68)
Viral infection
HCV-positive	152 (54%)
HBV-positive	70 (25%)
HCV, HBV-positive	13 (5%)
HCV, HBV-negative	48 (17%)
Median real MELD score	15 (6–45)
Preoperative treatments	222 (78%)
TACE	158 (56%)
PEI	30 (10%)
RF	63 (22%)
Liver resection	16 (6%)
Median AFP level at OLT (ng/mL)	9 (1–6826)
Median preoperative tumor number	2 (1–6)
Median preoperative tumor diameter (cm)	2.5 (0.8–5)
Down-staging to MC	39 (14%)
Fulfilling MC at OLT	224 (79%)
Fulfilling up-to-7 criteria at OLT	267 (94%)
Median tumor number at histology	1 (0–12)
Median tumor diameter at histology (cm)	2.5 (0–6)
Fulfilling MC at histology	208 (73%)
Fulfilling up-to-7 criteria at histology	249 (88%)
Tumor grading
G0–G2	143 (50.5%)
G3–G4	140 (49.5%)
Microvascular invasion	117 (41%)
Macrovascular invasion	3 (1%)
Post-OLT M-TOR inhibitors	43 (15%)

HCC: hepatocellular carcinoma. OLT: orthotopic liver transplantation. HCV: hepatitis C virus. HBV: hepatitis B virus. MELD: Model for End-stage Liver Disease. TACE: trans-arterial chemoembolization. PEI: percutaneous alcohol injection. RF: radiofrequency ablation. AFP: alpha-fetoprotein. MC: Milan criteria.