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Journal of Transplantation
Volume 2011 (2011), Article ID 175768, 9 pages
http://dx.doi.org/10.1155/2011/175768
Review Article

Primary Graft Failure after Heart Transplantation

1Heart & Lung Transplant Unit, St Vincent's Hospital, Darlinghurst, NSW 2010, Australia
2Cardiac Physiology and Transplant Program, Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia

Received 5 April 2011; Accepted 9 May 2011

Academic Editor: Andreas Zuckermann

Copyright © 2011 Arjun Iyer et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Primary graft failure (PGF) is a devastating complication that occurs in the immediate postoperative period following heart transplantation. It manifests as severe ventricular dysfunction of the donor graft and carries significant mortality and morbidity. In the last decade, advances in pharmacological treatment and mechanical circulatory support have improved the outlook for heart transplant recipients who develop this complication. Despite these advances in treatment, PGF is still the leading cause of death in the first 30 days after transplantation. In today's climate of significant organ shortages and growing waiting lists, transplant units worldwide have increasingly utilised “marginal donors” to try and bridge the gap between “supply and demand.” One of the costs of this strategy has been an increased incidence of PGF. As the threat of PGF increases, the challenges of predicting and preventing its occurrence, as well as the identification of more effective treatment modalities, are vital areas of active research and development.