Review Article
Primary Graft Failure after Heart Transplantation
Table 3
Pharmacological activation of prosurvival kinases in a model of donor heart preservation.
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1Agent(s) added to Celsior arresting and storage solution. Abbreviations/drug classes are as follows: GTN—glyceryl trinitrate (nitric oxide donor); Carip—cariporide, Zonip—zoniporide, (both sodium/hydrogen exchange inhibitors); INO 1153—poly(ADPribose) polymerase inhibitor; Neureg—recombinant human Neuregulin-1 peptide; EPO—erythropoietin. 2Recovery of cardiac output expressed as fold increase over Celsior-stored hearts (); 3increase in survival kinase phosphorylation over Celsior-stored hearts; : intense; : moderate; +: weak; 4nd-not determined; |