Engraftment of Insulin-Producing Cells from Porcine Islets in Non-Immune-Suppressed Rats or Nonhuman Primates Transplanted Previously with Embryonic Pig Pancreas
Figure 1
Sections of the islet-implanted kidney from a rat (a, b) or rhesus macaque (c–g) transplanted with E28 pig pancreatic primordia in mesentery followed by porcine islets in the renal subcapsular space stained using anti-insulin antibodies (a, c, and e) or control antiserum (b, d); or hybridized to an antisense (f) or sense (g) probe for porcine proinsulin mRNA. PT: proximal tubule. Arrows: positively staining cells (a, c, and e). Scale bars 10 um (a, b); 15 um (c, d), 7.5 um (e–g). Reproduced with permission from the American Society for Investigative Pathology [7] and from Organogenesis [8].
