Striated Muscle as Implantation Site for Transplanted Pancreatic Islets
Figure 2
PET imaging of intramuscularly transplanted islets using the VMAT2 ligand [18F]FE-DTBZ-d4 as PET tracer. An inbred C57BL/6 mouse was transplanted with 300 mouse islets to the left abdominal muscle. The islets were labeled with Q-tracker prior to implantation. One month later, the mouse was administered the PET tracer [18F]FE-DTBZ-d4 intravenously. The tracer uptake could be detected by a μPET/CT scanner after 60 minutes (right image, orange delineation). The corresponding location of the islets as determined by Q-tracker fluorescence emission is shown to the left.
