Journal of Transplantation / 2011 / Article / Tab 1

Review Article

Cyclosporine: A Commentary on Brand versus Generic Formulation Exchange

Table 1

Cyclosporine development timeline.

DateSignificant event

November 1983Sandimmune (cyclosporine) oral solution approval
March 1990Sandimmune (cyclosporine) capsule approval
July 1995Neoral capsules and solution approval (brand cyclosporine modified)
October 1998SangStat’s SangCya (generic cyclosporine modified) approval
January 2000Cyclosporine modified capsules (Sandoz) approval
May 2000Cyclosporine modified capsules (Gengraf, Abbott)
December 2000SangCya withdrawal
December 2000Cyclosporine modified capsules (Pliva) approval
December 2001Cyclosporine modified solution (Pliva) approval
May 2002Cyclosporine capsules (generic Sandimmune, Apotex) approval
September 2004Cyclosporine solution (generic Sandimmune, Morton Grove) approval
January 2005Cyclosporine modified solution (Novex) approval
March 2005Cyclosporine modified capsules and solution (Ivax) approval

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