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Journal of Transplantation
Volume 2011, Article ID 671571, 12 pages
Research Article

Prospective Changes in Health-Related Quality of Life and Emotional Outcomes in Kidney Transplantation over 6 Years

1Department of Psychology, National University of Singapore, 9Arts Link AS402/28, Singapore
2Unit of Behavioural Medicine, University College London, Riding House Street, London W1 8AA, UK
3Health Services Research Group, City University, London, College Building Room A224, St John Street, London EC1V 0HB, UK
4Department of Nephrology, University College, London, and Royal Free Hospital, Pond Street, London NW3 2QG, UK

Received 14 January 2011; Revised 30 March 2011; Accepted 3 May 2011

Academic Editor: Andreas Zuckermann

Copyright © 2011 Konstadina Griva et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Little is known on long-term outcomes in kidney transplantation. This study evaluated changes and predictors of generic and transplantation-specific health-related quality of life (HQoL) over six years in 𝑁 = 1 0 2 kidney transplant survivors using the Short-form Health Survey-36 and the Transplant Effects questionnaire. Mixed models analysis was used to determine long-term outcomes. Emotional HQoL improved over time: Mental Component score, Mental Health, Energy ( 𝑃 s = . 0 0 0 ). Physical HQoL deteriorated: Physical Component Score ( 𝑃 = . 0 0 1 ), Pain ( 𝑃 = . 0 0 2 ). LRD transplant recipients had greater decline in physical functioning ( 𝑃 = . 0 0 3 ) and PCS ( 𝑃 = . 0 0 0 ) compared to cadaver recipients. Worry about the transplant ( 𝑃 = . 0 3 6 ) and feelings of responsibility ( 𝑃 = . 0 0 8 ) increased significantly over time. Worry about the transplant and perceived ability to work predicted 12.7% and 31.1% in variance in MCS and PCS, respectively. Efforts should be made to maintain HQoL and emotional outcomes with ongoing monitoring and support programs throughout the course of posttransplant care.