How to Recondition Ex Vivo Initially Rejected Donor Lungs for Clinical Transplantation: Clinical Experience from Lund University Hospital
Figure 3
Flowchart showing the second part of the ex vivo reconditioning of donor lungs initially rejected donor lungs for clinical transplantation. During the second part of the process, the lungs are ventilated and the perfusate blood is oxygenated. When the temperature reaches 32°C, careful ventilation is started at 1 L/min. The ventilation rate is increased with one liter per increasing degree of perfusate from the lung (i.e., increasing lung temperature). The FiO2 was maintained at 1.0, and the respiratory frequency was gradually increased from 5 to 15–20 per min. The perfusion flow was limited by the pulmonary pressure (≤20 mmHg). The PEEP was gradually increased to 5 cm H2O at 37°C.
